His research focuses on WP5, which aims to dissect the signalling pathways that propel the malignization of clonal cells into tumour cells, as well as their interaction with the tumour microenvironment. Specifically, the research of his group will focuses on determining the mechanisms through which clonal/leukemic cells promote immune suppression, which is an important cause of morbidity and mortality in these patients. Also, based on his background in the field of cell migration and chemotaxis, they are studying the molecular pathways that mediate the recruitment of clonal and leukemic cells to the bone marrow and the network of interactions established in the bone marrow microenvironment.

As a co-investigator of the proposal, he also participates in the other WP, particularly those involved in the determination of novel biomarkers of clonal/leukemic cells (WP4), Coordination and management of the project (WP1) and dissemination and analysis of the project’s results (WP6)

Doctor Vicente-Manzanares received a B.Sc. in Chemistry from the Complutense University of Madrid in 1996 and a PhD from University Autónoma de Madrid, focused on the description of mechanisms of the morphological control of T lymphocytes during chemotaxis. He conducted a post-doctoral stay at the University of Virginia under the direction of Prof. Alan Rick Horwitz, where he identified mechanisms and process that control cellular polarity during the migration phase and specific functions of different isoforms of no-muscular myosin of class II in a variety of cellular and molecular contexts.

After his return in 2011 to Spain, under the Ramón y Cajal Research Programme of the Spanish Government (MINECO), he became a Professor at the Autónoma University in Madrid where he developed his teaching and research activity at the Institute for Health Research, at the University Hospital de la Princesa.

In 2016 he achieved a position of a Scientist of the Higher Council for Scientific Research of Spain (CSIC) within the Cancer Institute for Cell and Molecular Biology (CIC/IBMCC) in Salamanca and since March 2017 he runs Biophysics of Tumour Microenvironment Laboratory. His current research focuses at the cross-roads between biophysics, signalling and genetics of lymphoproliferative disorders and rare haematological diseases.

He has published more than 70 articles in the top peer-reviewed international journals, including Nature Cell Biology, Journal of Cell Biology, Journal of Cell Science, etc. He’s a senior editor of BMC Immunology, Cytoskeleton, IJMS, Cells and ETAT. His publications were quoted more than 9000 times, with an H-index = 43 (Google Scholar).